PAX9 and MSX1 transcription factor genes in non-syndromic dental agenesis
نویسندگان
چکیده
منابع مشابه
Genetic Characterization of Hereditary, Sporadic, Dental Agenesis: Research on Pax9 and Msx1 Genes Mutation
Objectives:The aim of this study is to find some genetic aspects of dental agenesis and, in particular, to analyze mutations in the MSX1 and PAX9 genes in individuals with non-syndromic dental agenesis. The aim is to enhance our understanding of the genetic basis of these anomalies and to provide an epidemiological overview regarding the incidence of agenesis in the population, by innovative, m...
متن کاملMutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis.
Tooth agenesis in human being is the most common congenital anomaly associated with dental development. Mutations in many genes such as MSH homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin A (EDA) and EDA receptor (EDAR) have been associated with familial form of this condition. However, in large majority of patients, genetic cause could not be identified. The primary aim of present s...
متن کاملMutational analysis of MSX1 and PAX9 genes in Portuguese families with maxillary lateral incisor agenesis.
The observation that certain patterns of tooth agenesis occur more frequently in individuals of the same family may suggest the existence of predisposing genetic factors. The aim of this study was to search for mutations in the PAX9 and MSX1 genes and to investigate their potential association with the maxillary lateral incisor agenesis (MLIA) phenotype in 12 Portuguese families, a total of 52 ...
متن کاملDentistry and molecular biology: a promising field for tooth agenesis management.
Tooth agenesis is the failure of tooth bud development, causing definitive absence of the tooth. It is the most common dental anomaly, affecting up to one-quarter of the general population. The main cause is related to abnormal function of specific genes which play key roles during odontogenesis, particularly MSX1 and PAX9. MSX1 is a transcription factor highly expressed in the mesenchyme of...
متن کاملMutations in WNT10A are present in more than half of isolated hypodontia cases.
BACKGROUND Dental agenesis is the most common, often heritable, developmental anomaly in humans. Mutations in MSX1, PAX9, AXIN2 and the ectodermal dysplasia genes EDA, EDAR and EDARADD have been detected in familial severe tooth agenesis. However, until recently, in the majority of cases (∼90%) the genetic factor could not be identified, implying that other genes must be involved. Recent insigh...
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ژورنال
عنوان ژورنال: Archives of Oral Biology
سال: 2011
ISSN: 0003-9969
DOI: 10.1016/j.archoralbio.2010.10.020